Transplant Systems Science Laboratory

We use advanced computational and statistical methods to inform how scarce donor lungs can provide the greatest benefit to society.

A network of transplant centers across the United States All 77 lung transplant centers listed in the SRTR source, including adult and pediatric programs, at their reported geographic locations. Planes fly from randomly selected locations in the contiguous United States to these centers. Flights are illustrative. Temple University Hospital — Philadelphia, PA Vanderbilt University Medical Center — Nashville, TN The Cleveland Clinic Foundation — Cleveland, OH Northwestern Memorial Hospital — Chicago, IL Duke University Hospital — Durham, NC CHI St. Luke's Health Baylor College of Medicine Medical Center — Houston, TX NY Presbyterian Hospital/Columbia Univ. Medical Center — New York, NY Cedars-Sinai Medical Center — Los Angeles, CA University of California San Francisco Medical Center — San Francisco, CA Jackson Memorial Hospital University of Miami School of Medicine — Miami, FL Massachusetts General Hospital — Boston, MA Houston Methodist Hospital — Houston, TX University of California at Los Angeles Medical Center — Los Angeles, CA St. Joseph's Hospital and Medical Center — Phoenix, AZ Ohio State University Medical Center — Columbus, OH NYU Langone Health — New York, NY Stanford Health Care — Stanford, CA Mayo Clinic Hospital Florida — Jacksonville, FL UT Southwestern Medical Center/William P. Clements Jr. University Hospital — Dallas, TX Barnes-Jewish Hospital — St. Louis, MO University of Wisconsin Hospital and Clinics — Madison, WI University of Washington Medical Center — Seattle, WA UF Health Shands Hospital — Gainesville, FL Corewell Health Grand Rapids Hospitals — Grand Rapids, MI Mayo Clinic Hospital Minnesota — Rochester, MN University of Minnesota Medical Center, Fairview — Minneapolis, MN Inova Fairfax Hospital — Falls Church, VA University of Pittsburgh Medical Center — Pittsburgh, PA Brigham and Women's Hospital — Boston, MA Hospital of the University of Pennsylvania — Philadelphia, PA University of California San Diego Medical Center — La Jolla, CA University of Utah Medical Center — Salt Lake City, UT Indiana University Health — Indianapolis, IN University of Colorado Hospital/Health Science Center — Aurora, CO Emory University Hospital — Atlanta, GA University of Virginia Health Sciences Center — Charlottesville, VA Tampa General Hospital — Tampa, FL Baylor University Medical Center — Dallas, TX Loyola University Medical Center — Maywood, IL Johns Hopkins Hospital — Baltimore, MD AdventHealth Orlando — Orlando, FL University of Alabama Hospital — Birmingham, AL North Shore University Hospital/Northwell Health — Manhasset, NY University of Michigan Medical Center — Ann Arbor, MI Montefiore Medical Center — Bronx, NY University Hospital, University of Texas Health Science Center — San Antonio, TX Mount Sinai Medical Center — New York, NY University of Chicago Medical Center — Chicago, IL Froedtert Memorial Lutheran Hospital — Milwaukee, WI Integris Baptist Medical Center — Oklahoma City, OK Jewish Hospital — Louisville, KY Medical University of South Carolina — Charleston, SC Keck Hospital of USC — Los Angeles, CA Henry Ford Hospital — Detroit, MI Newark Beth Israel Medical Center — Newark, NJ University of Iowa Hospitals and Clinics Transplant Programs — Iowa City, IA University of Maryland Medical System — Baltimore, MD Ochsner Foundation Hospital — New Orleans, LA Memorial Hermann Hospital, University of Texas at Houston — Houston, TX University of Kentucky Medical Center — Lexington, KY University of North Carolina Hospitals — Chapel Hill, NC University Hospitals of Cleveland — Cleveland, OH The Nebraska Medical Center — Omaha, NE Thomas Jefferson University Hospital — Philadelphia, PA Methodist Specialty and Transplant Hospital — San Antonio, TX Mayo Clinic Hospital Arizona — Phoenix, AZ VCU Health System Authority, VCUMC — Richmond, VA Banner University Medical Center-Tucson — Tucson, AZ Nationwide Children's Hospital — Columbus, OH Children's Hospital of Philadelphia — Philadelphia, PA Lucile Salter Packard Children's Hospital at Stanford — Palo Alto, CA UPMC Children's Hospital of Pittsburgh — Pittsburgh, PA Children's Hospital Medical Center — Cincinnati, OH Boston Children's Hospital — Boston, MA St. Louis Children's Hospital at Washington University Medical Center — St. Louis, MO Texas Children's Hospital — Houston, TX University of Texas Medical Branch at Galveston — Galveston, TX

Our purpose

A national system, seen from every angle.

U.S. lung allocation has steadily advanced, but today's transplant system is dynamic, interconnected, and difficult to evaluate with traditional methods alone. Our lab builds models that make those relationships visible—and policy alternatives testable before they affect patients.

Our work focuses on improving both fairness and utility: equitable access to transplant, improved recipient outcomes, and more effective stewardship of a scarce donor supply.

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Our research

Empirical research and simulation in lung transplantation

Explore COMET-Lung →
01

Methods + simulation

Develop statistical models and open-source simulations to study the transplant system and evaluate policy alternatives.

02

Allocation policy

Study how lung allocation policies shape candidate prioritization, access to transplantation, and use of the donor supply.

03

Equity

Examine socioeconomic and biological differences in access to transplantation and outcomes.

04

Outcomes

Study survival, donor and recipient risk factors, and the costs of care before and after transplantation.

People behind the models

Transdisciplinary expertise

Meet the team →

Research support

Funding

Optimizing Lung Transplant Benefit Using Agent-Based Simulation Modeling Approaches

Supported by the National Heart, Lung, and Blood Institute (NHLBI) through an R01 award to our multi-investigator project at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

View the NIH project record ↗
Award
R01HL153175
Institute
National Heart, Lung, and Blood Institute
Location
Cleveland, Ohio
Project period
June 2020 – April 2029
Principal Investigators
Maryam Valapour, MD, MPP
Jarrod Dalton, PhD
Johnie Rose, MD, PhD